فهرست نشریات علمی دسترسی آزاد ایران

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities havebeen described in association with ALL including osteoprosis and bone fractures. Different factors including thedisease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate,corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedicconditions and pain may be the first manifestation of acute leukemia and it is important for physicians torecognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverseeffect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of thedisease.