فهرست نشریات علمی دسترسی آزاد ایران

 Background: Antiphospholipid antibodies, including lupus anticoagulants and anticardiolipin (aCL) antibodies are associated with a wide variety of disorders including malignancies. The aim of this study was to investigate the prevalence and prognostic significance of aCL antibodies in Iranian patients with acute myeloblastic leukemia (AML).Methods: Forty-one patients with AML (27 men and 14 women, mean age 34.9±16.7 years) were included in this study. aCL IgG and aCL IgM antibodies were evaluated in patients before induction chemotherapy. All patients were followed up for chemotherapy response.Results: Antibodies (IgG, IgM or both) were found in 26 of 41 patients (63.4%), of whom 19 (46.3%) had a low titer, 6 (14.6%) a moderate titer and 1 (2.4%) a high antibody titer. No correlation was found between complete remission or relapse and aCL antibodies positivity.Conclusion: aCL antibody titers are slightly to moderately elevated in patients with hematologic malignancies,and these antibodies do not correlate with disease prognosis.