Primary Splenic Hodgkin’s Disease in a Patient with Chronic Granulomatous Disease, a Case Report

نویسندگان
Hosseini, M ID 1
Foroutan, HR ID 2
Geramizadeh, B ID 3
Alborzi, A ID 4
Ramzi, M ID 5

1 Department of Pathology, Transplant Research Center

2 Department of Pediatric Surgery, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Pathology, Transplant Research Center,

4 Department of Pediatric Infectious Disease, Prof. Alborzi Research Center

5 Hematology Research Center

doi
چکیده

 Here we report a 20-year-old male, a known case of chronic granulomatous disease (CGD), who presented with fever and splenomegaly. After splenectomy, primary splenic Hodgkin’s disease was diagnosed. Immunohistochemistry confirmed the diagnosis (positive CD15 and CD30). With chemotherapy, his fever was subsided and now after6 months, he is doing well. Although primary immune deficiencies have been reported to show an increased tendency to develop malignancies, until now there has been no report of a patient with CGD and Hodgkin’s disease. 

کلیدواژه‌ها
Chronic Granulomatous Disease, spleen, Hodgkin’s disease