Differentiation of Fanconi and Aplastic Anemia Using Chromosomal Breakage Test in Southern Iran
نویسندگان
1 Department of Immunology
2 Department of Immunology
3 Department of Immunology
4 Hematology Research Center, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
doi
چکیده
Background: Fanconi anemia (FA) is a chromosomal breakage disorder characterized by familial aplastic anemia(AA), various congenital anomalies, and a characteristic chromosomal response to clastogenic stress.Methods: In this study, chromosome breakage test was performed for 38 patients suspected of having FAand age-matched controls.Results: According to the results, ten patients were considered as FA cases and 15 patients with no chromosomalbreaks were considered as AA.Conclusion: Differentiation of FA from AA is very important because the primary treatment is different. Thistest should be done in every primary presentation of AA.
