Zn/La3⁺-Based MOFs: A Novel Approach for Controlled and Sustained Release of Captopril
نویسندگان
1 Department of Chemistry, Shahid Bahonar University, 76169-133, Kerman, Iran
2 Department of Chemistry, Payame Noor University, 19395-4697, Tehran
doi
10.30473/ijac.2024.71778.1302چکیده
This study presents the synthesis of Zn/La³⁺-based metal-organic frameworks (MOFs) using a co-precipitation assisted microwave method. Characterization through SEM and TEM revealed uniform nanoparticles around 80 nm. FT-IR spectroscopy confirmed the presence of key functional groups. Dynamic light scattering (DLS) showed highly uniform particle sizes. In vitro release studies of captopril from Zn/La³⁺/MOFs demonstrated a 41% release rate over 300 min, compared to 64% for pure captopril. Encapsulation within the MOF matrix ensured controlled and sustained drug release, with the first -order kinetic model fitting best. These Zn/La³⁺/MOFs show promise for enhanced and controlled drug delivery systems.
