فهرست نشریات علمی دسترسی آزاد ایران

Cyclosporine A (CSA) with intra- and inter-individual variability in absorptiveproperty needs individualized dose adjustment in patients receiving the drug. This studywas performed to compare cyclosporine C0 (before morning dose) and C2 (two hours aftermorning dose) levels in order to adjust the maintenance dose of CSA in stable renal transplantpatients in Shiraz, southern Iran.Methods: From October 2004 to June 2005, 64 kidney transplants of Nemazee Hospitalentered our study. All patients underwent renal transplantation for the first time exceptone subject who received the second transplant. All patients received three immunosuppressivedrugs of which CSA was administered in two divided doses in the form of microemulsion.The height, weight, blood pressure, periodical tests and C0 and C2 levels weredetermined at the time of referral, as well as one and 5 months later. The amount of CSAwas adjusted based on C0 levels of 100-250 ng/mL. The patients were divided into two C0subgroups with C0 levels of <100 and ≥100 ng/mL. In regard to C2, the two subgroupswere <800 and ≥800 ng/mL. In addition to CSA, cellcept and prednisolone were administeredto 47, immuran with prednisolone to 15, and only prednisolone to 2 patients.Results: Comparing the two subgroups of C0 and C2, no differences were observed betweenserum creatinine level, CSA doage and the drug complications. A significant correlationwas found between C0 and C2 levels, and also between C2 level and CSA dosage. Anegative correlation was seen between C0 level and serum creatinine. The coefficient ofvariation of the three samples of each patient was 10.89% for C0, and 8.94% for C2 withconstant drug regimen.Conclusion: As there was no significant difference between mean C0 and C2 levels, andrenal function at the start and the end of study, there seemed to be no need to recommendC2 level for follow up of renal transplantation.