Oral leukoplakia: Diagnosis and treatment

نویسندگان
Sørensen, Jens Ahm ID 1
Godballe, Christian ID 2
Henrik Thygesen, Torben ID 3
Larsen, Marie Kjaergaard ID 4

1 Professor, Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense, Denmark

2 Professor, Department of ORL-Head and Neck Surgery, Odense University Hospital, Odense, Denmark

3 Associate Professor, Department of Oral and Maxillofacial Surgery, Odense University Hospital, Odense, Denmark

4 Department of Oral and Maxillofacial Surgery, Odense University Hospital, Odense, Denmark

doi
چکیده

BACKGROUND AND AIM: Oral leukoplakia (OL) is a common premalignant lesion. The possible benefits of specific interventions in preventing a malignant transformation of OL are not well understood. This review assesses different invasive treatment techniques for OL and evaluate the optimal treatment possibilities.METHODS: A Medline (PubMed) search was conducted and heterogeneity between the studies was found, e.g., with regard to the OL lesions, patient groups, follow-up time, and definition of recurrence.RESULTS: The recurrence and malignant transformation rate after the different treatment methods were evaluated. The mean overall recurrence rate varied with the treatment method.CONCLUSION: A surgical treatment appears to decrease the risk of transformation but does not fully eliminate it. Follow-up should be done regardless of the surgical treatment.

کلیدواژه‌ها
Oral leukoplakia, Squamous Cell Carcinoma, Chemotherapy, Laser Ablation, Cryosurgery