فهرست نشریات علمی دسترسی آزاد ایران

The polygenic mode for inheritance of Vesicoureteral Reflux (VUR) is a debutable issue. Our study is aimed to investigate the correlation between HLA system and VUR. Materials: The study included thirty patients with VUR and sixty patients from kidney donors as control group. Initially the HLA formulas of each patient were detected according to racial­ geographical distribution as well as common and specific antigens. Then, the Relative Risk (RR) for the class I antigens of the HLA system was calculated and the X2 statistical test was performed for the antigens with RR>1 to establish a significant association between HLA system and VUR. Result: Increased frequency of the genes HLA-A9, HLA-844 were characterized by statistical analysis (RR>1, X2>3.84). Therefore, the significant correlation was found between VUR and HLA system (P<0.05). Conclusion: There are significant correlation between VUR and HLA-A9 and HLA-844. However, rnore study is necessary that these genes may become markers for VUR.