A new and efficient method for the synthesis of pyrazolo[3,4-d] pyrimidines catalyzed by iodine
نویسندگان
1 Department of Chemistry, Alzahra University, P.O. Box 1993891176, Tehran, Iran
2 Department of Chemistry, Alzahra University, P.O. Box 1993891176, Tehran, Iran
3 Department of Chemistry, Alzahra University, P.O. Box 1993891176, Tehran, Iran
4 School of Chemistry, College of Science, University of Tehran, 14155-6455, Tehran, Iran
doi
10.24200/sci.2018.21137چکیده
Fully substituents new pyrazolo[3,4-d]pyrimidines were synthesized. The synthesis starts with cyanomethylphenylketone that reacts with phenyl hydrazine to give the corresponding aminopyrazole. The latter undergoes a cyclocondensation with an N,N'-bis(arylmethylidene)arylmethane yielding the final product. Both synthetic steps are high-yielding (the overall yields between 65-78%). The newly synthesized compounds were characterized by 1H NMR, 13C NMR and elemental analysis
