Synergistic effect of carbomer polymer and graphene oxide nanoparticles on the rat wound healing process
نویسندگان
1 Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2 Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
3 Department of Basic Sciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
4 Department of Basic Sciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
5 Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
doi
10.22038/ijbms.2025.89073.19227چکیده
Objective(s): Wound healing is a multifaceted process involving inflammation, proliferation, and remodeling phases. Effective wound management requires materials that can promote tissue regeneration while preventing infections. Carbomer polymers are widely used in wound dressings due to their biocompatibility and water absorption properties, while graphene oxide nanoparticles have shown potential in enhancing cellular activities and antimicrobial effects. However, the combined effect of these materials on wound healing remains unexplored. Materials and Methods: A composite hydrogel was prepared by incorporating graphene oxide nanoparticles into a carbomer polymer matrix. The hydrogel’s physicochemical properties, including swelling behavior, mechanical strength, and drug release profile, were evaluated. In vivo wound healing studies were conducted on Sprague-Dawley rat models, with wounds treated using the composite hydrogel and a control group.Results: The composite hydrogel demonstrated superior swelling capacity and mechanical stability. In vivo studies revealed significantly faster wound closure rates in the composite hydrogel-treated group (P<0.05). Histological analysis showed enhanced tissue regeneration, reduced inflammation, and increased collagen deposition in the treated wounds.Conclusion: The synergistic combination of carbomer polymer and graphene oxide nanoparticles effectively enhances wound healing by improving hydrogel properties and promoting tissue regeneration. This composite material holds significant potential for advanced wound care applications.
