The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways
نویسندگان
1 Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
5 Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
10.22038/ijbms.2025.81908.17719چکیده
Diosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations, improving cardiovascular health and modulating immunity and anti-oxidant properties. Neuroinflammation and oxidative stress are associated with numerous neurological disorders. This study aims to review the neuroprotective potentials of diosmin and hesperidin, focusing on their effects on oxidative stress and inflammatory conditions. A scientific literature search was conducted using specific keywords in various databases, including PubMed, Web of Science, Google Scholar, Embase, and Scopus.Diosmin and hesperidin demonstrated protective effects in managing a variety of neurological disorders, such as epilepsy, neuropathy, depression, anxiety, insomnia, autism, glioblastoma, traumatic brain injury, cerebral ischemia-reperfusion, Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, neurotoxicity, and multiple sclerosis through the regulation of various signaling pathways. Hesperidin and diosmin exhibit promising neuroprotective effects that underscore their potential as natural multi-targeted therapeutic agents for treating neurological disorders through diverse cascades.
