Formulation Development of Terbinafine Hydrochloride Using β-Cyclodextrin Complexation and Its Effect on Antifungal Activity
نویسندگان
1 Department of Industrial Engineering, College of Engineering, University of Business and Technology, Jeddah 21448, Saudi Arabia
2 Department of Chemistry, AAA College of Engineering and Technology, Amathur, Sivakasi, Tamil Nadu, India
3 Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India
doi
10.48309/jmcs.2026.543777.2863چکیده
This effort focuses on research functioned aimed at exploring the influence of β-Cyclodextrin (β-CD) on the solvation capacity of the antifungal drug Terbinafine Hydrochloride (TBF HCl). Non-bonding interactions in encapsulation complexes of β-CD and TBF HCl were formed using manual blending, solvent evaporation, and freeze-drying methods. The interaction between the solution phases was examined through phase solubility studies, while solid-phase inclusion was confirmed using FT-IR, ¹H-NMR, XRD, DSC, and SEM analyses. The phase solubility studies confirmed a favorable host–guest interaction between TBF HCl and β-CD, with an apparent stability constant (K₁: ₁) of 320.68 M⁻¹, suggesting the formation of a stable and soluble inclusion complex. The findings from the in vitro release assessment highlighted that the β-CD: TBF HCl inclusion complex exhibited a maximum drug release rate 120.7%. Antifungal activity tests conducted on Candida albicans demonstrated that all the prepared inclusion complex systems were effective. Molecular docking analyses provided insights into the specific portions of TBF HCl that interact with β-CD at the molecular level. These findings collectively support the suitability of the β-CD: TBF HCl host-guest mechanism for the topical delivery of TBF HCl.
