فهرست نشریات علمی دسترسی آزاد ایران

Patients with uncontrolled type 2 diabetes mellitus (UT2DM) can be detected by assessing HbA1c levels. An increase in oxidative reactions is a metabolic consequence of uncontrolled diabetes mellitus that impacts both the macrovascular and microvascular systems. HSP70 levels may indicate this negative effect. Further research is required to explore the correlation between HbA1c and HSP70 and its clinical implications, which may contribute to advancements in the management and treatment of UT2DM in the future. The aim of this study is to determine the profile of HbA1c and HSP70 levels in uncontrolled UT2DM patients. This research used an observational method with a cross-section design which was carried out at PKU Muhammadiyah Gamping Yogyakarta Hospital. 125 patients were studied in the age range of 31-65 years old including 69 men and 46 women. HbA1c levels were checked using the boronate affinity method and HSP70 levels were checked using the ELISA method. Data analysis was done through the Mann-Whitney U and Kruskal Wallis difference tests and the Spearman correlation test at a significance level of α=0.05. The results showed that 39 subjects (31.2%) had moderate control and 86 (68.8%) had poor control. All subjects had increased HSP70 levels above normal limits. HSP70 levels in the poor control group were significantly higher than those in the moderate control group (p=0.000). There was no correlation between HbA1c levels and HSP70 levels (r=0.022, p=0.812). There was no correlation between HSP70 levels and age (r=0.039, p=0.663). The values of HSP70 and HbA1c did not correlate. There was no correlation between HSP70 levels and UT2DM period (r=0.049, p=0.584). HSP70 levels in the group of participants with poor control were substantially higher than those in the group with moderate control in patients with uncontrolled diabetes mellitus.