Memorizing Al-Quran Increases Serum BDNF Levels

نویسندگان

1 Physiology Department, Faculty of Medicine, Universitas Trisakti, 11440 Jakarta, Indonesia

2 Neurology Department, Faculty of Medicine, Universitas Trisakti, 11440 Jakarta, Indonesia

3 Obstetry and Gynecology Department, Faculty of Medicine, Universitas Trisakti, 11440 Jakarta, Indonesia

4 Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq

5 Physiology Department, Faculty of Medicine, Universitas Trisakti, 11440 Jakarta, Indonesia

6 Physiology Department, Faculty of Medicine, Universitas Trisakti, 11440 Jakarta, Indonesia

7 Al-Azhar Syifa Budi, 16967 Cibubur, Indonesia

doi
10.26655/JMCHEMSCI.2025.4.2
چکیده

Cognitive function refers to mental processes involving knowledge, information processing, and reasoning. Memorizing the Al-Quran can stimulate the production of brain-derived neurotrophic factor (BDNF), a crucial protein that plays a significant role in promoting the survival of neurons and synapses involved in memory and learning. BDNF levels can be used to assess cognitive function. Mild Cognitive Impairment (MCI) is often evaluated using the MOCA-INA score. This study utilized an observational analytic design with a cross-sectional approach. Extensive studies have explored the effects of learning and memorizing the Al-Quran on cognitive abilities in adults. In this study, cognitive function was evaluated by measuring serum BDNF levels and the MOCA-INA score. The study involved 88 adult participants aged 18-30 years who met the inclusion and exclusion criteria. The BDNF levels in the 11-20 juz group (45540.25 ± 11661.84 pg/mL) and the 21–30 juz group (46005.6 ± 7304.86 pg/mL) were significantly higher than those in the <10 juz group (37414.88 ± 10229.63 pg/mL). The difference between Quran memorization and BDNF levels was statistically significant (p = 0.002). However, the MOCA-INA scores did not show a significant difference across the three groups (p = 0.696). The amount of Al-Quran memorized is significantly associated with serum BDNF levels. Memorizing the Al-Quran may provide cognitive benefits, particularly in enhancing brain neurotrophic factors, and could be a beneficial practice for improving cognitive function in Muslims.

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