فهرست نشریات علمی دسترسی آزاد ایران

Dyslipidemia is a risk factor for cardiovascular disease, the primary cause of mortality worldwide. Elevated LDL-c initiates atherosclerosis, while PUFAs have the potential to improve lipid profiles and prevent cardiovascular disorders. This study aimed to measure and analyze the effect of administering sacha inchi seed oil (SISO) cultivated in Indonesia to male Rattus norvegicus rats with dyslipidemia, focusing on changes in lipid profiles (TG, LDL-c, TC, HDL-c, and ox-LDL), IL-6, and IL-10 level. The study employed a true experimental design using a randomized post-test control group design. The intervention was 32 rats for 4 weeks, divided into 4 groups: healthy, dyslipidemia, and dyslipidemia rats receiving 3 ml and 4 ml SISO. Lipid profile assessments were conducted using direct enzymatic methods, CHOD-PAP, and ELISA to measure ox-LDL, IL-6, and IL-10 levels. Statistical analysis used a paired t-test, One-way ANOVA followed by LSD, and Kruskal-Wallis followed by Mann Whitney test. The results showed a significant decrease in LDL-c and TC levels and an increase in IL-10. Although IL-6 levels significantly differed, they did not reduce pro-inflammatory cytokines. TG levels decreased, and HDL-c increased, although not significantly, and there was no significant change in ox-LDL levels. It is suggested that PUFAs in SISO may enhance PPAR and RCT activities while inhibiting DGAT enzymes. The findings indicate that SISO supplementation could improve lipid profiles and exert anti-inflammatory effects compared to standard and dyslipidemic rats. However, further research with longer intervention periods is needed to evaluate the long-term benefits and antioxidant properties of SISO.