فهرست نشریات علمی دسترسی آزاد ایران

A frequent complication of Sepsis is Acute Kidney Injury (AKI), which is believed to stem from insufficient blood flow to the kidneys. AKI is often associated with a low MPP, specifically below 60 mmHg. Another crucial parameter is the RRI, which is measured non-invasively using Doppler ultrasound. RRI is frequently employed as an AKI predictor for patients in ICUs and has been observed to increase significantly in individuals experiencing shock. The objective of this study was to investigate the relationship between MPP and RRI. A cross-sectional study was conducted in 2022 at the ICU of RSUP H Adam Malik Medan, focusing on patients with Sepsis. Participants in the study underwent two examinations: a central venous pressure assessment to evaluate MPP, and a Doppler ultrasound to measure RRI. The methodology section has been clarified to provide justifications for the exclusion criteria, specifically addressing why patients in ICU for less than 24 hours were excluded. This study included 57 participants, males constituting the majority (n = 32; 56.1%). The mean age was 48.5 years. The study also revealed an average body mass index of 24.48 kg/m2 amongst the patients. In addition, the study recorded a mean heart rate of 101.73 beats per minute, median systolic and diastolic blood pressures of 114 mmHg and 102 mmHg, respectively, and an average mean perfusion pressure of 76.79 mmHg. The investigation further noted a mean glomerular filtration rate of 73.21 ml/minute and an average renal resistive index of 0.72. AKI was observed in 29 patients (50.9 %). There is a positive and weak correlation between MPP and RRI in Sepsis patients. Implications include the importance of early detection of MPP and RRI in guiding sepsis management. Recommendations for further studies include exploring long-term outcomes and alternative therapies.