No Prominent SOD and CAT Lung Expression of Rats Due to Exposure to Low-Density Polyethylene in The Air
نویسندگان
1 Department of Environmental Health, Faculty of Public Health, Universitas Airlangga, Surabaya Indonesia
2 Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya Indonesia
3 Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Selangor Malaysia
4 Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor Malaysia
5 Faculty of Medicine, Universitas Hang Tuah, Surabaya Indonesia
6 Department of Environmental Health, Faculty of Public Health, Universitas Airlangga, Surabaya Indonesia
doi
10.26655/JMCHEMSCI.2025.1.3چکیده
Microplastics are plastic particles less than 5 mm in diameter that contaminate the environment. Humans and animals can inhale microplastics measuring 2 μm to 1 mm in the air. There has been limited research on inhalation exposure to low-density polyethylene (LDPE) microplastics. This study aimed to investigate the Reactive Oxygen Species (ROS) in the Wistar strain of Rattus norvegicus due to exposure to LDPE in the air. This study is an experimental study using a post-test control group design on the Wistar strain of Rattus norvegicus. Five experimental groups (X1 to This result showed the SOD and CAT enzymes were not present or active. There was no difference between groups of both SOD and CAT enzymes. The microplastic particles in the blood (/mL) were identified in each intervention group which was 6.80 ± 2.58 (X1), 17.67 ± 9.02 (X2), 35.83 ± 12.22 (X3), 41.17 ± 14.72 (X4), and 57.50 ± 6.47 (X5) while in control group was 1.80 ± 1.30 with fragments being the most dominant form of microplastics. It can be concluded that ROS was not seen due to the dose, chamber condition, and exposure technique should be intratracheal. The greater the dose of LDPE exposure, the greater the average microplastics in the blood of the Wistar strain of Rattus norvegicus in both the control and intervention groups.
