The Relationship between Chronic Stress and the Pathogenesis of Neurodegenerative Diseases: A Comprehensive Literature Review
نویسندگان
1 Ministry of Health, Wadi Aldawaser Hospital, Saudi Arabia
2 Ministry of Health, Al-Sulail Hospital, Saudi Arabia
3 Ministry of Health, Long-Term Care Hospital, Riyadh, Saudi Arabia
4 Ministry of Health, Sultana Health Center in Riyadh, Saudi Arabia
5 Ministry of Health, Maternity and Children's Hospital in Dammam, Saudi Arabia
6 Ministry of Health, Irada Mental Health Hospital, Saudi Arabia
7 Ministry of Health, West Al Rass Health Care Center, Saudi Arabia
8 Ministry of Health, King Salman Centre for Kidney Diseases, Saudi Arabia
9 Ministry of Health, Iman General hospital, Saudi Arabia
10 Ministry of Health, Mental Health Hospital Qurayyat, Saudi Arabia
11 Ministry of Health, King Salman Centre for Kidney Diseases, Saudi Arabia
12 Ministry of Health, Arada Complex and Mental Health in Dammam, Saudi Arabia
13 Ministry of Health, Specialized Dental Center in Riyadh, Saudi Arabia
14 Ministry of Health, Eradah complex for mental health Riyadh, Saudi Arabia
15 Ministry of Health, Eradah complex for mental health Riyadh, Saudi Arabia
16 Ministry of Health, Eradah complex for mental health Riyadh, Saudi Arabia
doi
10.26655/JMCHEMSCI.2024.12.5چکیده
Neurodegenerative illnesses, such as Parkinson's and Alzheimer's, have been linked to the pathogenesis of chronic stress. Comprehending the complex interplay of stress, glucocorticoids, and neurodegeneration is essential for identifying potential treatment targets. The influence of chronic stress on neurodegenerative illnesses was investigated by comprehensive literature review, with an emphasis on the physiological, molecular, and epigenetic processes at play. Studies on the impact of stress on glucocorticoid regulation, hippocampal susceptibility, and epigenetic changes were evaluated. Chronic stress and increased glucocorticoid levels were shown to intensify neurodegenerative mechanisms, leading to cognitive deficits, neuronal degeneration, and synaptic dysfunction. Epigenetic alterations resulting from early-life stress were recognized as significant determinants of susceptibility to neurodegenerative disorders. The results show how glucocorticoids, neurodegeneration, and chronic stress interact in complex ways. Focusing on stress-related pathways and epigenetic processes may offer therapeutic opportunities in Alzheimer's and Parkinson's illnesses.
