فهرست نشریات علمی دسترسی آزاد ایران

Eucheuma cottoni (EC) contains the active compounds such as phenol, hydroquinone, flavonoids, and triterpenoids which act as antioxidants. A common food ingredient used to improve flavor, monosodium glutamate (MSG) can be harmful to the body if used excessively or over an extended period. This study aims to demonstrate how EC extract affects the body weight and cholesterol levels of Ratus norvegicus which MSG induces. Three identical groups including 24 experimental animals were created: GI is for untreated, and GII stands for the group that was exposed to MSG for 14 days at a dose of 4 g/kg BW, dissolved in an intragastric sonde solution every 7 days. GIII was induced by 4 g/kg BW of MSG, just as GII did, and given 400 mg/kg BW of Euchema cottoni extract diluted in 0.5% CMC Na solution on the tenth day by intragastric sonde per day for 14 days. Statistical test results for initial and final body weight variables using the paired sample t-test showed significant results (p= 0.062), meaning the body weight of the experimental animals in all groups did not significantly change before or after treatment. This shows that the body weight of the experimental animals was unaffected by the 14-day induction of MSG at a dose of 4 g/kg BW. Cholesterol level variable, MSG induction can increase total cholesterol levels (p=0.03). When comparing the cholesterol levels of the group administered EC extract and induced by MSG to the group induced by MSG alone, there was no discernible change (p=0.134), this shows that the EC extract could not reduce the cholesterol levels of experimental animals induced by MSG.