The Biochemical Foundations of Genomics in Personalized Nursing: Clinical Implications and Practice
نویسندگان
1 Ministry of Health Office, Ministry of Health, Saudi Arabia
2 Al-Amajiya Health Center, Ministry of Health, Saudi Arabia
3 King Fahd Central, Ministry of Health, Saudi Arabia
4 Mental Health Will Hospital, Ministry of Health, Saudi Arabia
5 Al Rasras Khamis Mushait Health Care Center, Ministry of Health, Saudi Arabia
6 Dhurma Health Center, Ministry of Health, Saudi Arabia
7 Eastern Health Cluster, Hazam um Alsahek PHC, Ministry of Health, Saudi Arabia
8 Jeddah Al Rehab Health Care Center, Ministry of Health, Saudi Arabia
9 Ministry of Health Al Murooj Health Center, Ministry of Health, Saudi Arabia
10 Irada for Mental Health, Ministry of Health, Saudi Arabia
11 Ministry of Health Branch in Al-Jouf Region, Ministry of Health, Saudi Arabia
12 Sbaia Health Center, Ministry of Health, Saudi Arabia
13 Erada Hospital and Mental Health, Ministry of Health, Saudi Arabia
14 King Salman Hospital in Riyadh, Ministry of Health, Saudi Arabia
15 Eastern Health Cluster, Hazam um Alsahek PHC, Ministry of Health, Saudi Arabia
doi
10.26655/JMCHEMSCI.2024.11.20چکیده
The rapid advancements in genetic science, driven by the Human Genome Project and Next-Generation Sequencing (NGS), has transformed healthcare, facilitating the emergence of customized therapy. This perspective considers health and illness as the result of intricate interactions between an individual's genes and both internal and external environmental influences. Incorporating omics sciences-such as genomics, transcriptomics, proteomics, epigenomics, and metabolomics- into nursing practice is essential for addressing changing care requirements and using the advantages of individualized care plans and illness prevention. However, the shift toward precision medicine also presents challenges, including ''translational anxiety'' and the need for effective integration of genetic knowledge into nursing education and practice. This review explores the influence of genetic information on individualized care plans and illness prevention within nursing practice. It examines advancements in genomic technologies and its consequences for comprehending complex disorders, highlighting the genotype-phenotype correlation and the significance of intermediate omics layers (proteome, transcriptome, and metabolome). The review examines the concepts of precision medicine, namely P4 medicine (predictive, preventative, personalized, and participatory), and its ramifications for nursing responsibilities in diagnosis, treatment, and patient education. The incorporation of genetics into nursing practice presents significant potential for improved patient outcomes. Nurses are distinctly qualified to spearhead the execution of precision health by delivering pharmacogenetically informed drug therapy, personalized care, educating patients, and families on genomic testing, and offering essential insights on the practicality of emerging technologies. Nonetheless, many obstacles persist, notably the need for improved genetic literacy among nurses and the development of strategic initiatives to incorporate omics sciences into nursing education, research, clinical practice, and health policy. The omics revolution signifies a transformative change in healthcare, requiring a proactive response from the nursing profession. By integrating genetic information and encouraging interprofessional cooperation, nurses may assume a pivotal role in converting genomic insights into concrete therapeutic advantages, enhancing diagnostic precision, customizing therapies, and advancing disease prevention. By embracing the biochemical principles of genomics and fostering interprofessional collaboration, nurses can assume a pivotal role in translating genomic insights into tangible therapeutic benefits, personalizing therapies, and advancing disease prevention in the era of precision medicine.
