Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome
نویسندگان
1 Medical Surgeon Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico
2 Department of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City, C.P. 04510, Mexico
3 Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacán, Mexico City, C.P. 04510, Mexico
4 Medical Surgeon Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico
5 Histology Laboratory, Morphology and Function Unit, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico
6 Histology Laboratory, Morphology and Function Unit, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico
7 Phytochemistry Area, Postgraduate Degree in Botany, Campus Montecillo, Postgraduate College, Km. 36.5 México-Texcoco Road, Montecillo, Texcoco, State of Mexico, C.P. 56230, Mexico
8 Postgraduate Studies and Research Section, Higher School of Medicine, National Polytechnic Institute, Mexico City, 11340, Mexico
doi
10.22038/ijbms.2023.66530.14601چکیده
Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba “chaca” is a medicinal plant used in Mexico for hypertension and empirical therapy. In this study, were examined the effects of ethanol extract of B. simaruba on metabolic syndrome.Materials and Methods: For induction of metabolic syndrome, 20% fructose was used, and it was administered in the water and food to male Wistar rats for 12 weeks, after administering ethanol extract of B. simaruba intragastrically (100 and 200 mg/kg/day) for 6 weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin 1-7 were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified. Results: Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba.Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, anti-oxidant, and renoprotective effects.
