Assessment of Immunohistochemical Expression of Cyclin D1 and E-Cadherin in Laryngeal Squamous Cell Carcinoma
نویسندگان
1 Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
2 Otorhinolaryngology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
3 Otorhinolaryngology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
4 Otorhinolaryngology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
5 Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
6 Pathology Department, Nasr City Cancer Center, Cairo, Egypt
7 Oncologic Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
8 Otorhinolaryngology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
9 Otorhinolaryngology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
10 Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
11 Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
12 Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
13 Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
14 Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
15 Otorhinolaryngology Division, Surgery Department, College of Medicine, Al-Baha University, Al-Baha, Saudi Arabia
16 Pathology Department, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia
17 Pathology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt
18 Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
doi
10.26655/JMCHEMSCI.2024.8.1چکیده
Laryngeal cancer, particularly the squamous cell carcinoma subtype, is prevalent all over the world and is characterized by a poor prognosis and high mortality rates. Currently, no definitive prognostic markers exist for predicting the behavior of the tumor. The aim of this study is to examine the correlation between cyclin D1 and E-cadherin expression with some clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC). 60 cases of LSCC were retrospectively studied concerning the clinicopathological features and the potential prognostic role of cyclin D1 and E-cadherin expression in laryngeal carcinoma, using immunohistochemical staining scores on paraffin-embedded cancer tissues from patients who were treated with surgical excision. Reduced E-cadherin expression was significantly correlated with tumor grade (p = 0.0288), T stage (p = 0.041), and lymph node metastasis (p = 0.003). Regarding Cyclin D1, a statistically significant correlation was found with lymph node metastasis (p=0.019). In contrast, cyclin D1 expression was not significantly correlated with TNM stage or tumor grade (p=0.99 and 0.66, respectively). Evaluating expression of cyclin D1 in conjunction with E-cadherin expression in laryngeal squamous cell carcinoma may prove beneficial in identifying patients with lymph node metastasis. Tumor grade, stage, and nodal metastasis can significantly affect E-cadherin expression in patients with LSCC. However, further studies using genetic testing are recommended to assess the role of E-cadherin in tumor progression.
