Exploring the Multifunctional Potential of 4-((4-Phenyl-5-Thioxo-1, 2, 4-Triazol-3-yl) Methoxy) Coumarin: A Comprehensive Study on Its Corrosion Inhibition, Antioxidant, and Antibacterial Properties
نویسندگان
1 Production and Metallurgy Engineering Department, University of Technology, Baghdad 10001, Iraq
2 Materials Engineering Department, University of Technology-Iraq, Baghdad 10001, Iraq
3 Biomedical Engineering Department, University of Technology-Iraq, Baghdad 10001, Iraq
4 Energy and Renewable Energies Technology Centre, University of Technology, Baghdad 10001, Iraq University of Al-Ameed, Karbala, 56001, Iraq
5 Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, University Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia
6 Energy and Renewable Energies Technology Centre, University of Technology, Baghdad 10001, Iraq University of Al-Ameed, Karbala, 56001, Iraq
doi
10.26655/JMCHEMSCI.2024.7.5چکیده
The strategic synthesis of 4-((4-Phenyl-5-Thioxo-1,2,4-Triazol-3-yl)methoxy)coumarin (PTTC) derived from 4-hydroxycoumarin is imperative, given its industrial, therapeutic relevance, and structural adaptability. This investigation delves into its multifaceted potential, particularly focusing on its anticorrosion, antibacterial, and antioxidant properties. Antibacterial efficacy against a spectrum of bacterial strains including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, and Staphylococcus aureus was evaluated via the disk diffusion method, revealing robust microbiological activity with inhibition zones ranging from 11 to 28 mm. Furthermore, PTTC exhibited notable antioxidant prowess, demonstrating a maximum scavenging capacity of 95% in the DPPH radical scavenging assay. These results underscore PTTC's versatility as a therapeutic agent with promising applications. Its corrosion resistance potential for mild steel in 1.0 M hydrochloric acid was studied using weight loss methods. Parameters that influence corrosion inhibition such as PTTC concentration, which is a structural parameter, environmental temperature and immersion duration were all studied systematically. Particularly, the PTTC achieved high inhibition efficiencies that were at 96% at a 1.0mM concentration at 303K. The adsorption process on the metal surface was in accordance with the Langmuir adsorption isotherm, and both the experimental and theoretical results were in good agreement. The study presented discusses the PTTC's various functions and thereby, making it a good choice for different therapeutic purposes, corrosion prevention, and antioxidative activities.
