Exploring the Multifaceted Biological Activities of 4-((5-Amino-1, 3, 4-Thiadiazol-2-yl) Methoxy) Coumarin: Antioxidant, Antibacterial, and Antifungal Properties
نویسندگان
1 Department of Pharmacy, Al-Farabi University College, Baghdad 10001, Iraq
2 Materials Engineering Department, University of Technology-Iraq, Baghdad 10001, Iraq
3 Scientific Research Center, Al-Ayen University, Thi-Qar, Iraq
4 Biomedical engineering Department, University of Technology-Iraq, Baghdad 10001, Iraq
5 University of Al-Ameed, Karbala, 56001, Iraq
6 Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia
doi
10.26655/JMCHEMSCI.2024.7.7چکیده
This study is aimed at the preparation and characterization of the coumarin derivative, 4-((5-amino-1, 3, 4-thiadiazol-2-yl) methoxy) coumarin (ATMC) and the determination of the antitumor activity of the compound. The compound was prepared through a synthetic route starting with 4–hydroxycoumarin by undergoing a sequence of chemical reactions. The confirmation of ATMC structure was done by different spectroscopy methods such as FT-IR, 1H-NMR, 13C-NMR, and also further chemical analysis. In a biological activity profiling experiment, antibacterial activity, antifungal activity, and antioxidant activity of the compound ATMC were examined. The in vitro efficacy of antimicrobial activity was shown by the zone of inhibitory zone which was ranged 15 to 22 mm against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, and Staphylococcus aureus. In addition to this antifungal study also shows that the ATMC has strong inhibition against Aspergillus niger and Candida alb. Based on the provided data, it can be suggested that ATMC possesses various biological effects, which de-monstrates the prospect of its application as a therapeutic drug.
