Catalyzing Kaempferol from Broccoli Fruit (Brassica oleracea var. italica) on Tyrosinase Protein for Regulation of Melanin Synthesis in-Slico
نویسندگان
1 Department of Cosmetology and Beauty, Tourism and Hospitality Faculty, Universitas Negeri Padang, Padang, 25131, Indonesia
2 Departement of Biochemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia
3 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
4 Senior Lecture (Non-Clinical) Anatomy, Newcastle University Medicine Malaysia (NUMed), Johor, Malaysia
5 Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia
6 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Indonesia
doi
10.26655/JMCHEMSCI.2024.4.6چکیده
This study investigates the effectiveness of Kaempferol, a compound extracted from broccoli (Brassica oleracea var. italica), as a catalyst in controlling melanin production through its interaction with the tyrosinase protein. Utilizing a variety of computational tools, including Pymol, Pyrex, Protein Plus, and Lepinski Rule software, the study explores Kaempferol's binding affinity with tyrosinase and its molecular properties. The findings reveal Kaempferol's notable binding scores with tyrosinase and its structural stability as indicated by RMSD analysis. Furthermore, Protein Plus software confirms the interaction between Kaempferol and tyrosinase protein. Lipinski's analysis of Kaempferol shows it meets key pharmacokinetic properties like molecular weight, hydrogen bond formation potential, and reactivity. These insights establish a preliminary understanding of Kaempferol's role as a catalyst in melanin synthesis regulation, suggesting its potential application in treating skin pigment disorders.
