Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
نویسندگان
1 Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, East Java, Indonesia
2 Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, East Java, Indonesia
3 Institute of Ocean and Earth Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia
4 Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, 42 Karl Liebknecht str., Yekaterinburg, 620075, Russia
5 Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, East Java, Indonesia
6 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
7 Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, 26 Talalikhin Str., Moscow 109316, RussiaFaculty of Biotechnology and Food Engineering, Ural State Agrarian University, 42 Karl Liebknecht
doi
10.26655/JMCHEMSCI.2024.4.8چکیده
Herbal medicines are currently widely used, both in developing and developed countries. Herbal medicines with combinations of ingredients have complex chemical compositions, so identification of therapeutic effects is needed to support the use of these drugs in clinical decisions. The study aims to identify the therapeutic effects of the herbal medicine Sambiloto-Ginger-Turmeric (SIJAKUN) using in silico. A search for secondary metabolites in Sijakun was obtained from the KnapSack database, and then treatment predictions were carried out using WAY2DRUGPASS. After that, pharmacokinetic analysis was carried out using SwissADME. Protein targets that can interact with SIJAKUN using STITCH DB and SEA targets. Hypergeometric Test with Multiple Testing Correction Benjamini-Hochberg False Discovery Rate (FDR) was used as a statistical test. The combination of herbal medicine SIJAKUN has dominant properties as an anti-inflammatory and P53 stimulant via the JUN/AP-1 pathway. SIJAKUN meets the pharmacokinetic criteria to be used as a drug. However, it is less effective for absorption in the intestine. SIJAKUN can be used as an anti-inflammatory and anti-apoptosis drug, but laboratory tests and further research are needed regarding drug preparations to increase absorption in the intestine.
