Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice
نویسندگان
1 Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China
2 Department of Physiology, Guangzhou University of Chinese Medicine, Guangdong, P.R. China
3 Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China
4 School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India
5 School of Biological Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore
6 Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China
7 School of Biological Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore
8 Department of Biology, Clarkson University, Potsdam, New York, United States
doi
10.22038/ijbms.2022.63044.13932چکیده
Objective(s): The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors.Materials and sMethods: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was investigated in non-social and social environments through home-cage emergence and social interaction tests, respectively, whereas aggressive behaviors were examined under the female intruder test. Results: We observed significant social behavioral deficits with pronounced social and non-social anxiogenic phenotypes in female Ttc9a-/- mice. When tested for aggressive-like behaviors, we found a reduction in offense in Ttc9a-/- animals, suggesting that TTC9A deficiency impairs the offense responses in female mice. Conclusion: Future study investigating mechanisms underlying the social anxiety-like behavioral changes in Ttc9a-/- mice may promote the understanding of social and anxiety disorders.
