A facile and green three-component synthesis of 2-amino-3-cyano-7-hydroxy-‎‎4H-chromenes on grinding

نویسندگان
Matloubi Moghaddam, F. ID 1
Lotfi Kalahroodi, E. ID 2
Koushki Foroushani, B. ID 3

1 Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Tehran, P. O. Box: 11155-9516, Iran

2 Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Tehran, P. O. Box: 11155-9516, Iran

3 Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Tehran, P. O. Box: 11155-9516, Iran.

doi
چکیده

A simple, efficient and one-pot method has been developed for the synthesis of densely functionalized aryl derivatives of 2-amino-3-cyano-7-hydroxy-4H-chromene by the domino Knoevenagel-Michael-cyclization reactions of aromatic aldehydes, resorcinol and malononitrile in the presence of a catalytic amount of Na2CO3 under grinding conditions.

کلیدواژه‌ها
Multicomponent reactions (MCRs), Green chemistry, 4H-chromene derivatives, resorcinol, malononitrile