Curcuma Longa May Prevent Endothelial Dysfunction in Rattus Norvegicus Exposed by Soot Particulate through Changes of OxLDL and eNOS Levels
نویسندگان
1 Department of Parasitology, Faculty of Medicine, Brawijaya University, Malang, Indonesia
2 Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia
3 Postgraduate Program Students, Faculty of Medicine, Brawijaya University, Malang, Indonesia
4 Department of Internal Disease, Faculty of Medicine, Brawijaya University, Malang, Indonesia
doi
10.26655/JMCHEMSCI.2023.11.23چکیده
The purpose of this study is to prove the efficacy of Curcuma longa (turmeric) extracts against soot (carbon black)-exposed rats with Ox-LDL and eNOS levels. A total of 30 rats were divided into 5 groups with 6 rats in each group. Negative control group (C-) received no treatment. The positive control group (C+) exposed to soot at a concentration of 1064 mg/m3 for 8 hours. Treatment group T1 was exposed to soot at 1064 mg/m3 for 8 hours + Curcuma longa at 1 mg/kg body weight. T2 group was exposed to soot at 1064 mg/m3 for 8 hours + 2 mg curcuma longa mg/kg body weight, and T3 group were exposed to soot at of 1064 mg/m3 for 8 hours + curcuma longa 3 mg/kg body weight. The result of T3 group had lower Ox-LDL levels and higher eNOS levels, and also the difference was significant (p>0.05) than the C+ group. We conclude that the treatment of rats exposed to 1064 mg/m3 soot particles for 8 hours with Curcuma longa extract at a dose of 3 mg/kg body weight reduced Ox-LDL levels and increased eNOS levels because curcumin from Curcuma longa extract effective to break the chain reaction from lipid peroxidation, inhibit LOX-1 expression, prevent LDL modification into ox-LDL, and decrease coupled eNOS levels that prevent NO and GSH degradation.
