Conjugation of Cortistatin Peptide with Gold Nanoparticles Synthesized to Investigate Anti-Inflammatory Effects in Allergic Asthma
نویسندگان
1 Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran
2 Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran
3 Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
doi
10.26655/JMCHEMSCI.2023.1.3چکیده
In this study, conjugation between Cortistatin peptide and gold nanoparticles was performed for effective drug delivery of peptide to lung tissue to investigate its anti-inflammatory anti-asthmatic effects. To create conjugation between metal nanoparticles and biomolecules, there are different strategies based on chemical or physical interactions, which are selected according to the desired goals. Attaches based on chemical interactions have more specificity and selectivity, and for the intended purpose, drug delivery to the lung tissue is more desirable. This work performed conjugation based on chemical interactions using linker molecules to achieve higher specificity and selectivity. The binding of Cortistatin peptide to gold nanoparticles in this work was 80%, which indicates that the binding through the linker molecules is well done.
