Metallo-Drugs as Promising Antibacterial Agents and Their Modes of Action
نویسندگان
1 Department of Chemistry, University of Botswana, P/Bag UB 704, Gaborone, Botswana
2 Department of Chemistry and Forensic Sciences, Botswana International University of Science and Technology, Private Bag 16, Palapye, Botswana
3 Department of Applied Sciences, Botho University, PO Box 501564, Gaborone, Botswana
doi
10.26655/JMCHEMSCI.2022.6.24چکیده
Antibiotic resistance has been a growing worldwide public health issue. The World Health Organization (WHO) has stated that the search for new antibiotics is slow, while antibiotic resistance is growing. WHO has also declared that antibiotic resistance is one of the top 10 global public health threats facing humanity in the 21st century. Therefore, this review discusses the potential of metal-based drugs as antibacterial agents from the period of the early 2000s to date. The review reveals that a lot of preliminary work has been done to assess these as potential drugs. However, their mode of action is faintly described. Furthermore, a few examples of metal-based drugs assessed for their modes of action are described. These compounds are ideal as they have been observed to work with one or more modes of action and they are also able to induce or increase activity of free organic compounds once bound to the metal. Nonetheless, more studies are needed to understand the modes of action of other transition metal compounds.
