Solvent-free Synthesis and Antimicrobial Activity of Dihydroquinazolinone Derivatives
نویسندگان
1 Department of Medicinal Chemistry, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Medicinal Chemistry and Radiopharmacy, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Pharmacognosy, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Department of Medicinal Chemistry, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
5 Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
6 Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
doi
10.26655/JMCHEMSCI.2022.3.3چکیده
In this research, a new series of dihydroquinazolinone analogs (4a-f) was synthesized using a one-pot reaction supporting solvent-free conditions at the presence of SnCl2.2H2O as catalyst. All final products were proved by FT-IR, 1H-NMR, and 13C-NMR analysis. The preliminary antimicrobial activity was assessed against Gram-negative (Escherichia coli, Pseudomonas aeruginosa), Gram-positive (Staphylococcus aureus, Bacillus subtilis, Lactobacillus rhamnosus), and antifungal activities against Candida albicans. Most of the synthesized derivatives revealed considerable activity, significantly compounds 4d and 4e at 0.25 mg/mL concentration had the highest activity against P. aeruginosa. Also, the MIC of compound 4d was 0.25 mg/mL against B. subtilis, and L. rhamnosus. Furthermore, the tested molecules demonstrated moderate antifungal activities against the C. albicans.
