Solar light photo-catalyzed condensation of aldones with 4-phenylthiosemicarbazide, a green chemistry approach
نویسندگان
1 Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
2 Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10Av. E. Mounier B-1200 Brussels, Belgium, E.U.
3 Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
4 Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
5 Pharmacognosy Research group (GNOS), Louvain Drug Research Institute, Université Catholique de Louvain, 1200 Brussels , Belgium, E.U.
6 Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
doi
10.26655/jmchemsci.2020.3.4چکیده
A significant photo-activating effect was evidenced upon investigating the condensation of aldehydes and ketones with 4-phenylthiosemicarbazide in the absence of any type of catalyst (either acido-basic or nucleophilic catalysis). Actual yields were not found superior to those obtained using nucleophilic catalysts; however, the reaction can be run at room temperature with the absence of an additional solvent. A positive hydrophobic effect was also noted. Furthermore, it was found that, the described photo-chemical method did not require an expensive and energy-consuming photo-chemical equipment since the whole process was carried out using natural solar light in regular laboratory glass ware.
