Study of heterocyclic-fused pyridazinone analogues having phosphodiestrase-IV inhibitor activities as anti-inflammatory agents
نویسندگان
1 Department of Pharmacy, Guru Ram Das (PG) Institute of Management and Technology, Dehradun, (Uttarakhand), 248009, India
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, PO Box 840, Saudi Arabia
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, PO Box 840, Saudi Arabia
doi
10.26655/jmchemsci.2020.2.3چکیده
Phosphodiesterase-IV (PDE- IV) inhibitors which are effective anti-inflammatory agents have forced researchers to find new PDE-IV inhibitors with less adverse effects than conventional anti-inflammatory drugs. Some pyridazinone derivatives reduced inflammation by inhibiting PDE-IV enzyme and acted as anti-inflammatory agents. The new pyridazinone derivatives will be more suitable than the currently developed pyridazinone compounds for future studies and could be developed as more safe anti-inflammatory drugs for humans.
