Pentoxifylline Protects the Rat Liver Against Fibrosis and Apoptosis Induced by Acute Administration of 3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy)
نویسندگان
1 Department of Anatomy, Islamic Azad University Tehran Medical Branch, Tehran, Iran
2 Department of Anatomy, Islamic Azad University Tehran Medical Branch, Tehran, Iran
3 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran
4 Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
doi
10.22038/ijbms.2013.1351چکیده
Objective(s): 3,4-Methylenedioxymethamphetamine (MDMA) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in liver cells. The present study aimed to investigate the effects of pentoxifylline (PTX) on liver damage induced by acute administration of MDMA in Wistar rat. Materials and Methods: Animals were administered with saline or MDMA (7.5 mg/kg, IP) 3 times with 2 hr intervals. PTX (200 mg kg, IP), was administered simultaneously with last injection of MDMA in experimental group. Results: The concomitant administration of pentoxifylline and MDMA decreased liver injury including apoptosis, fibrosis and hepatocytes damages. Conclusion: Our results showed for the first time that PTX treatment diminishes the extent of apoptosis and fibrosis caused by MDMA in rat liver.
