Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats
نویسندگان
1 Division of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2 Division of Pharmacology and Toxicology, department of basic sciences, school of veterinary medicine, shiraz university, shiraz, iran
3 Division of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
doi
10.22038/ijbms.2012.4903چکیده
Objective(s) This study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. Materials and Methods Twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. After 2 weeks, serum total cholesterol, triglycerides, HDL-c, LDL-c and VLDL-c concentrations were assayed and liver sections examined for fatty liver changes. Data were analyzed by ANOVA method and P< 0.05 was considered significant. Results Dexamethasone increased all lipid parameters as compared to control (P< 0.05). Lipid parameters in group 3, were lower than group 2 (P< 0.05) except for HDL-c which remained statistically the same. Moderate fatty liver changes were observed in one third of rats in dexamethasone group. Rats in groups 1, 3 and 4 had no sign of fatty changes. Conclusion Niacin positively affects glucocorticoid-induced dyslipidemia and fatty liver changes in rats.
