Preparation and Identification of New 1,4-Bis(5,3-substituted-2,3-dihydro-1H-pyrazole-1-yl)buta-1,4-dione Derivatives with their Antibacterial Effect Evaluation
نویسندگان
1 Chemistry Department, College of Sciences, University of Kirkuk, Kirkuk, Iraq
2 College of Dentistry, University of Kirkuk, Kirkuk, Iraq
3 Chemistry Department, College of Sciences, University of Kirkuk, Kirkuk, Iraq
4 Directorate of Education, Ministry of Education, Kirkuk, Iraq
doi
10.22034/chemm.2023.365060.1614چکیده
A new series of 5,3-substituted-2,3-dihydro-1H-pyrazole derivatives (P1-10) have been synthesized via a cyclization reaction of substituted chalcones with succinichydrazide. Structures of the prepared compounds were identified by FT-IR, and some of them were characterized by Nuclear Magnetic Resonance for proton 1H-NMR and Nuclear Magnetic Resonance for carbon 13C-NMR. The heat of formation (HF) and steric energy (SE) have been calculated using (MOPAC) and (MM2) methods, respectively, using (CS-Chemoffice-version 6.0) program. Additionally, the biological activity for final products has been evaluated against gram-positive (staphylococcus aureus and staphylococcus epidermidis) and negative bacteria (escherichia coli and pseudomonas aeruginosa).
