فهرست نشریات علمی دسترسی آزاد ایران

New substituted coumarins derivatives were synthesized by using nitration reaction to produce ‎different nitro coumarin isomers which were separated from these isomers by using different solvent, and the ‎reduction of nitro compounds was done to give corresponding amino coumarins. Temperature and ‎reaction time of reaction were very important factors in determining the most productive nitro isotopes‎. A low temperature for three hours was sufficient to give a high product of a ‎compound 6- nitro coumarin while increasing the temperature for a period of twenty-four hours that gave ‎a high product of 8-nitro-coumarin. The synthesized compounds were confirmed by FT-IR, 1H-NMR, and ‌‎13C-NMR spectroscopy and all final compounds were tested for their antifungal and antibacterial activity. Some ‎of them showed more biological activity than the standard drugs. Some synthesized compounds ‎showed a variation in their anti-oxidant activities according to IC50 values.  Some of these compounds had a ‎very good antioxidant compared with ascorbic acid as a standard.‎