A multi-component reaction for the direct access to 4,4'-(phenylmethylene)bis(1H-pyrazol-5-ol)-3-carboxylates using nano-NiZr4(PO4)6 in water
نویسندگان
1 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran
2 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran
3 School of Chemistry, College of Science, University of Tehran, Tehran 14155-6455, Iran
doi
10.24200/sci.2018.20491چکیده
An efficient synthesis of 4,4'-(phenylmethylene)bis(1H-pyrazol-5-ol)-3-carboxylates is achieved by one pot pseudo five-component reaction of phenylhydrazine, acetylenedicarboxylates and aromatic aldehydes in the presence ofnano-NiZr4(PO4)6 at 60°C in water. Nano-NiZr4(PO4)6 has been characterized by powder X-ray diffraction (XRD) and scanning electronic microscopy (SEM). Use of simple and readily available starting materials, excellent yields in short times, reusability of the catalyst, little catalyst loading and simple operational procedures are some of the important features of this protocol.
