In Vitro Screening of Anticancer Activity of Dregea volubilis and Leptadenia reticulata Using Sulforhodamine B (SRB) Assay
نویسندگان
1 Department of Pharmacology, RR College of Pharmacy, Bangalore – 560090, India
2 Department of Pharmacology, Aditya Bangalore Institute of Pharmacy Education and Research, Bangalore -560064, India
3 Department of Pharmacology, MVM College of Pharmacy, Bangalore – 560064, India
4 Department of Pharmaceutical Chemistry, School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry – 607402, India
5 Department of Pharmacology, School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry - 607402, India
6 Department of Pharmacology, Nandi Medical College and Research Institute, Ckikkaballapur, Karnataka, India
7 Department of Pharmacognosy, School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry-607402, India
doi
10.48309/ajgc.2026.553231.1845چکیده
The present study aimed to evaluate the anticancer potential of Dregea volubilis and Leptadenia reticulata extracts using the Sulforhodamine B (SRB) assay against selected human cancer cell lines. Ethanolic extracts of both plants were tested, and Adriamycin was used as the reference standard. The GI₅₀ values of Dregea volubilis and Leptadenia reticulata extracts were found to be 62.4 µg/mL and 78.6 µg/mL, respectively, while Adriamycin exhibited a GI₅₀ value of 1.2 µg/mL under similar conditions, indicating comparatively lower potency of the plant extracts. Among the two, Dregea volubilis showed better cytotoxic activity. The findings suggest that the bioactive constituents of these plants may serve as leads for the development of novel anticancer agents. This study provides the first comparative evidence of the anticancer potential of these traditional medicinal plants, supporting their ethnopharmacological relevance.
