Green Extraction and In Vivo Screening of Myrica Nagi Bark for Antidepressant, Antidiabetic, and Analgesic Potentials
نویسندگان
1 Department of Pharmacology, Himachal Institute of Pharmaceutical Education and Research, Bela, Nadaun Himachal Pradesh, India
2 Department of Pharmaceutical Chemistry, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Sasaram (Rohtas) Bihar, 821305, India
3 Department of Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Hyderabad, Telangana 501 301, India
4 Department of Chemistry and Biochemistry, Lamar University, 4400 MLK Blvd, Beaumont, Texas 77710, USA
5 Department of Pharmaceutics, AVIPS, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India
6 Department of Chemistry and Biochemistry, Lamar University, 4400 MLK Blvd, Beaumont, Texas 77710, USA
7 Department of Pharmacognosy & Phytochemistry, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, India
8 Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana 500001, India
9 Faculty of Pharmaceutical Science, Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, India
10 Department of Chemistry, The Pharmaceutical College, Samaleswari Vihar, Tingipali, Barpali 768029, Odisha, India
doi
10.48309/AJGC.2026.537235.1786چکیده
The Myricaceae family's subtropical shrub known as Myrica nagi Hook (syn. Myrica esculenta Buch. & Ham) is frequently referred to as boxberry. It is an average to large, dioecious, evergreen tree with a trunk circumference of 92.5 cm, and light brown to black bark. Several chemical compounds in M. nagi have been shown to be potent antioxidants, and M. nagi has been linked to various pharmacological activities. This study analyzed the antidepressant, antidiabetic, and analgesic properties of Myrica nagi (M. nagi) ethanol bark extract in Swiss albino mice. The extraction was performed using the maceration technique. The forced swimming test (FST), tail suspension test (TST), and alloxan-induced diabetic model were used alongside analgesic assays, such as the hot plate and acetic acid-induced writhing test. The proposed activities were evaluated using these procedures. Antidepressant action was observed in the FST and TST at a higher dose (400 mg/kg). Significant antidiabetic action was observed in alloxan-induced diabetic mice when the bark extract was administered at 200, 300, or 400 mg/kg. The ethanol extract of the bark at three concentrations (200, 300, and 400 mg/kg) showed substantial analgesic effects in both the hot plate and acetic acid-induced tests. According to our findings, M. nagi bark extract has antidepressant, antidiabetic, and analgesic properties. However, further studies are needed to isolate bioactive ingredients and better understand the molecular mechanisms and modes of action of these pharmacological benefits.
