Greener Alternative in Organic Synthesis: Aqueous Knoevenagel Condensation Reaction Catalysed by [Bmim][OAc] Ionic Liquid with Antimicrobial Evaluation
نویسندگان
1 School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India, PIN 431606
2 Chemistry Department, Faculty of Education and Applied Sciences-Hajjah, Hajjah University, Yemen
doi
10.48309/AJGC.2025.522309.1743چکیده
The Knoevenagel condensation of malononitrile or ethylcyanoacetate with different aldehydes, using 1-butyl-3-methylimidazolium acetate [Bmim][OAc] in an aqueous medium, was successfully done. This proposed approach offers several advantages, such as economy, short reaction time, eco-friendly and environmentally benign reaction medium, simple workup, recyclability of the ionic liquid, accelerated reaction rate, and high yields (90-97%). The resulting Knoevenagel adducts (3c-f, 3l-q) were further evaluated for their antimicrobial activity.
