Synthesis, Characterization, Antioxidant, and Antimicrobial Evaluation of Novel (E)-4-(Substituted Benzylideneamino)phenol Derivatives Featuring Heteroaryl and Aryloxy Substituents
نویسندگان
1 Department of PharmD, Faculty of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, Jordan
2 Department of Chemistry, Faculty of Science, Jadara University, P.O. Box 733, Irbid 21110, Jordan
3 Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Jadara University, P.O. Box 733, Irbid 21110, Jordan
4 Department of Chemistry, Faculty of Science, Jadara University, P.O. Box 733, Irbid 21110, Jordan
5 Department of PharmD, Faculty of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, Jordan
6 Department of Pharmacy, Faculty of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, Jordan
7 Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Jadara University, P.O. Box 733, Irbid 21110, Jordan
doi
10.48309/chemm.2026.551489.2018چکیده
In the present study, four 4-aminophenol derivatives, (E)-4-(((5-bromothiophen-2-yl)methylene)amino)phenol, (E)-4-(((5-bromofuran-2-yl)methylene)amino)phenol, (E)-4-(((5-nitrofuran-2-yl) methylene) amino)phenol, and 4 (E)-4-((3-(benzyloxy)-4-methoxybenzylidene) amino)phenol, were synthesized and characterized by FT-IR, 1H-NMR, and 13C-NMR. The synthesized compounds were tested for antimicrobial (Gram-positive and Gram-negative bacteria) and antioxidant activities. Compounds G2 and H2 showed moderate activity against Staphylococcus aureus compared to the standard Novobiocin. In contrast, compounds E2, F2, and H2 exhibited medium-range activity against Pseudomonas aeruginosa, while only compound H2 showed medium-range activity against Escherichia coli. The newly synthesized compounds showed significant antioxidant activity (72.5% ± 0.43), (67.4% ± 0.68), (77% ± 1.03), and (60% ± 0.73) compared to ascorbic acid (76% ± 0.30). The present study delineated the broad-spectrum antimicrobial and antioxidant activities of the synthesized compounds.
