An Electrochemical Sensor based on ZnO Nanoparticles-Incorporated MWCNTs for Sensitive Voltammetric Determination of Sertraline
نویسندگان
1 Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
2 Department of Ecology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
3 Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
doi
10.48309/chemm.2025.532919.1979چکیده
The present study was conducted to offer a simple, cost-effective, and robust electrochemical sensing platform based on ZnO nanoparticles-incorporated multi-walled carbon nanotubes modified screen-printed carbon electrodes (ZnO NPs/MWCNTs/SPCE) for the voltammetric determination of sertraline. Cyclic voltammetry (CV) studies revealed that ZnO NPs incorporated MWCNTs on the surface of SPCE can effectively facilitate electron transfer and increase the active surface area, thereby enhancing the electrocatalytic performance for sertraline oxidation. Under the optimal experimental conditions and parameters, the DPV measurements showed that the oxidation peak currents were linearly proportional to the concentrations of sertraline in the range of 0.05 µM to 350.0 µM with a detection limit (LOD) of 0.02 µM. Finally, ZnO NPs/MWCNTs/SPCE achieved accurate determination of sertraline in urine and tablet samples with a relative standard deviation (RSD) of less than 3.7% and satisfactory recovery, demonstrating its good potential in practical applications.
