Synthesis and Characterization of New 1,3,4-Thiadiazole Derivatives Containing Azo Group from Acid Hydrazide and Studying Their Antioxidant Activity
نویسندگان
1 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
2 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
doi
10.22034/chemm.2022.338522.1489چکیده
The present report describes the synthesis of new the synthetic route that started by the reaction of acid hydrazide derivatives with ammonium thiocyanate to give compounds 1a-d. 1,3,4-thiadiazole derivatives 2a-d were synthesized by the reaction compounds 1a-d with concentration sulfuric acid. Finally, the reaction 1,3,4-thiadiazole derivatives 2a-d with sodium nitrate and hydrochloric acid in 0-5 °C to form diazonium salt, then diazonium salt reacted with 4-dimethylaminobenzaldehyde to synthesize azo compounds 3a-d. These new synthesized products were characterized by FT-IR, 1H-NMR for some of them and were studied regarding the effect of preparing derivatives on antioxidant activity.
