Synthesis and Biological Activities of Some New Derivatives Based on 5-Styryl-2-amino-1,3,4-thiadiazole
نویسندگان
1 Department of Chemistry, College of Science for women, University of Baghdad, Baghdad, Iraq
2 Department of Chemistry, College of Science for women, University of Baghdad, Baghdad, Iraq
3 Department of Chemistry, College of Science for women, University of Baghdad, Baghdad, Iraq
4 Department of Chemistry, College of Science for women, University of Baghdad, Baghdad, Iraq
5 Department of Chemistry, College of Science for women, University of Baghdad, Baghdad, Iraq
6 Department of Chemistry, College of Science for women, University of Baghdad, Baghdad, Iraq
doi
10.22034/chemm.2022.2.1چکیده
In this research, 5-Styryli-2-amino-1, 3, 4-thiadiazole [C1] was prepared from the reaction of acid 3-phenyl propenoic acid with thiosemicarbazide. Amic acids [C2-C5] were synthesized by reactive compound [C1] with different types of hydrides, then [C2, C4] were treated with AC2O in the presence of NaOAC as a catalyst giving Imide compounds [C6, C7]. The structure of the new derivatives was confirmed via FT-IR spectroscopy, some of which were confirmed via 1H-NMR spectroscopy. Three of these new derivatives were evaluated by their Esherichiacoli, Staphylococcus, and Rhizopus emporium.
