A Facile and Green Approach for One-Pot Synthesis of New Pyrrole Derivatives by Three-Component Reaction Between Pyrrole, Arylglyoxals and Meldrum's Acid
نویسندگان
1 Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan 7718897111, Iran
2 Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, 7718897111, Iran
3 Department of Chemistry, Islamic Azad University, Rafsanjan Branch, Rafsanjan, Iran
doi
10.22036/org.chem.2023.299025.1263چکیده
An efficient one-pot three-component reaction of pyrrole with arylglyoxal derivatives and Meldrum’s acid (MA) in water at room temperature afforded 2,2-dimethyl-5- (2-oxo-2-aryl-1- (1H-pyrrol-2-yl) ethyl) -1,3-dioxane-4,6-dione derivatives under catalyst-free conditions in high yields. Products were isolated and purified by simple filtration and washing with diethyl ether and their structures were established from their IR and NMR spectroscopic data.
