Simple, Highly Efficient Synthesis 2-Amino-4-phenyl-4,5,6,7-tetrahydropyrano[3,2-c]carbazole-3-carbonitrile Derivatives Using Silica Supported Dodeca-Tungstophosphoric Acid DTP/SiO2
نویسندگان
1 Department of Chemistry, Dr. D. Y. Patil ACS Womens College, Pimpri, Pune-411014; Savitribai Phule Pune University, Pune, India
2 Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM. Carretera Toluca-Atlacomulco Km 14.5, Toluca, Estado de México, 50200, México
doi
10.22034/jaoc.2022.332760.1049چکیده
The one-pot multicomponent efficient and easily operational protocol has been developed for the synthesis of tetrahydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives. The methods work via the multicomponent reaction between 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one , aldehyde and malononitrile catalyzed by the silica-supported dodeca tungstophosphoric acid (DTP/SiO2) catalyst. The protocol is practically green, milder reaction condition, higher yield, with short reaction times and recyclability of the catalyst.
