Bi(OTf)3 as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Milder Conditions
نویسندگان
1 Dr. Arvind B. Telang Senior College of Arts, Science and Commerce, Pradhikaran Nigdi, Pune – 411044, India
2 Dr. Arvind B. Telang Senior College of Arts, Science and Commerce, Pradhikaran Nigdi, Pune – 411044, India
3 Department of Chemistry, Dr. D Y Patil ACS College Pimpri Pune; 411018, Affiliated to Savitribai Phule Pune University, Pune, India
doi
10.22034/jaoc.2022.336265.1052چکیده
A simple, eco-friendly friendly and efficient procedure for the synthesis of Mannich Baseshas been developed via multi-component and one-pot reactions of various aldehydes with aniline, and acetophenone and catalytic amount of Bi(OTf)3 reagent in a DCM solvent.The Bi(OTf)3 acts as a highly potent catalyst ( 0.5 to 1 mol%) for a for the synthesis of Mannich base (1,3-diphenyl-3-(phenylamino)propan-1-one). This protocol is also compatible with a variety of hetero aldehyde carbonyl compounds in excellent yields. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.
