Pyridazine Derivatives Act as Phosphodiesterase-III, IV, and V Inhibitors
نویسندگان
1 Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, 21955, Saudi Arabia
2 Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India
doi
10.22034/jaoc.2021.289851.1024چکیده
Pyridazine derivatives are significant bioactive molecules having wide range of biological activities. Phosphodiesterase (PDE) enzymes, particularly PDE-III, PDE-IV, and PDE-V are inhibited by some pyridazine compounds. PDEs are cyclic nucleotide-hydrolyzing enzymes that regulate intracellular levels of the secondary messengers (cAMP and cGMP), cell activities and their specific inhibitory effects for the treatment of various disorders. PDE isoenzyme selective inhibitors include PDE-III inhibitors for congestive heart failure (CHF), PDE-IV inhibitors for inflammatory disorders, and PDE-V inhibitors for erectile dysfunction. The PDE-V inhibitor should be utilized in pulmonary hypertension. In this article, study the PDE activities of various pyridazine compounds.
